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Rather than inducing desensitization, a chronic morphine treatment could promote a compensatory increase in intracellular cAMP level (also named cAMP overshoot or ACase superactivation) (Avidor-Reiss et al., 1995) and is believed to play a direct role in tolerance (Duman et al., 1988

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Drug Interactions: Inform your provider if you use antibiotics, antiepileptics, or methotrexate

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All site-specifically acetylated GST-tagged SnCE1 proteins were affinity purified and their oligomerisation state was analyzed by analytical SEC as described above

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