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The very first descriptions of the far-UV CD spectra of randomly disordered polypeptides (which can be served as an oversimplified IDP) can be found in a 1962 paper by George Holzwarth (19372024), Walter Bruno Gratzer (19322021), and Paul Mead Doty (19202011) (Holzwarth et al., 1962), and in follow-up 1965 papers by Holzwarth and Doty (Holzwarth and Doty, 1965) and Lon Velluz (19041981) and Michel Legrand (Velluz and Legrand, 1965), who reported corresponding data for the poly-L-glutamic acid and poly-L-lysine at neutral pH

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