This dual action provides more comprehensive glucose regulation than single-receptor medications
It is a GIP/GLP-1 dual agonist, engaging two incretin receptors rather than one which is why it sits in its own class relative to semaglutide, liraglutide, and dulaglutide
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In cardiovascular outcome trials (CVOTs) such as Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients (EMPA-REG OUTCOME), CANagliflozin cardioVascular Assessment Study (CANVAS) and The Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) [6], they reduced the onset and progression of DKD, which was confirmed in the dedicated kidney trial The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), which showed a canagliflozin-induced risk reduction for ESKD in people with DKD by 32% [7]
The Room Temperature Mistake: We've seen researchers leave a reconstituted vial on the lab bench for days
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