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The iPLEDGE Program requires registration of all wholesalers distributing isotretinoin, all healthcare professionals prescribing isotretinoin, all pharmacies dispensing isotretinoin, and all male and female patients prescribed isotretinoin

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The potential protective effect of GLP-1RAs in stroke demonstrated in animal experiments [27] was at least partially confirmed by the clinical results of the LEADER and SUSTAIN-6 studies in patients with T2DM [68]

To fully integrate GLP-1 receptor agonists into HS management, high-quality randomized controlled trials are needed to evaluate their efficacy, safety, and role as monotherapy or adjunctive treatment

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