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The science of Microdosing GLP-1 Broad clinical potential: Commonly used to treat type 2 diabetes and weight management, GLP-1 medications act on GLP-1 receptors located in the brain, gut, and immune system, impacting multiple biomarkers. Recent studies have begun exploring low doses of GLP-1 medications for broader health goals beyond glucose control and weight loss. Emerging research in healthspan and longevity: In a series of studies, low doses of GLP-1 receptor agonists were shown to modulate inflammatory pathways, support mitochondrial function, and lower the risk of cognitive decline in study participantsgiving Microdosing GLP-1 promising potential for extending healthspan
Research [3] suggests that MC1R activation may also be linked to the regulation of nucleotide excision repair mechanisms, a critical pathway involved in the removal of ultraviolet associated DNA lesions
For example, luteolin, a plant-derived flavonoid, downregulates the proinflammatory cytokines in macrophages and inhibits the production of nitric oxide and pro-inflammatory arachidonic acid by blocking the nuclear factor B (NF-B) signaling pathway (174)
A Long-Awaited Breakthrough We've heard for awhile now that the semaglutide drugs (Ozempic, WeGovy, and Rybelsus) have been game changers in helping patients to lower their blood sugar and lose weight
[1] Zepbound may delay gastric emptying, potentially reducing oral contraceptive effectiveness for 4 weeks after initiation or dose escalation, requiring backup contraception during these periods
Munir N, Khilji SA, Shabir M, Sajid ZA (2021) Exogenous application of ascorbic acid enhances the antimicrobial and antioxidant potential of Ocimum sanctum L
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