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Cyclophosphamide and ifosfamide, both used in cancer treatment, undergo metabolism to produce acrolein, which is a significant concern because it induces oxidative stress and can lead to hemorrhagic cystitis (120)
Depletion of free carnitine is likely to occur as a result of the activation of conjugation of acyl radicals, which accumulate in the disorders of respiratory chain and oxidative phosphorylation
The Prohibited List is updated annually and comes into effect on 1 January every year, and any changes to the Prohibited List are made public every year in early October for changes applicable to the upcoming year
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