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It promoted hepatic differentiation of human umbilical cord mesenchymal stem cells via activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway, which in turn alleviated liver fibrosis in mouse models [49]
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Ethanol feeding has been demonstrated to increase the translocation of intestinal lipopolysaccharide (LPS) to the liver via the portal vein, where it activates the KCs into an M1 phenotype favoring the production of proinflammatory cytokines [104]
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