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This localized distribution in the hypothalamus is significant as it aligns with the proposed effects of SEM in the brain, such as neuroprotection

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Anxiety disorders like panic attacks, post-traumatic stress disorder (PTSD), or generalized anxiety disorder are characterized by low GABA levels in certain brain regions.[ref] Additionally, people with an anxiety disorder may have overactivation in the amygdala caused by low GABA.[ref] Anxiety (and depression) are complex disorders with many variables involved, so while GABA may play a role, anxiety disorders are likely multifactorial for most people