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FIGURE 14 The available structural data on the GLP-1GLP-1R system reveal that GLP-1 occupies the deep transmembrane pocket of the GLP-1R and establishes several intermolecular interactions with crucial residues on the N-terminus, ECL2, TM1, TM2, TM5, TM6, and TM7 of GLP-1R (Figure 14), which are also sustained over the duration of MD simulations

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LC-MS/MS, liquid chromatography-tandem mass spectrometry

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