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RENAL IMPAIRMENT: No dose adjustment required for renal impairment, but monitor closely in severe renal impairment due to dehydration risk from GI side effects

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Heitmann J, Kreutz J, Aldudak S, Schieffer E, Schieffer B, Schfer A-C

When CYP3A4 activity drops, medication levels in your body can rise unexpectedly, potentially increasing side effects or changing how the drug works

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