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Among gut-derived uremic toxins, indoxyl sulfate and p-cresyl sulfate are largely protein bound in the blood circulation (mostly to albumin) and thus poorly cleared by diffusive dialysis procedures (75)

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These facts, together with increasing comorbidities in patients with IBD, imply that urgent, more complex, novel therapeutic strategies in the treatment are needed

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When it occurs, it is typically temporary and linked to digestion or hydration changes early in treatment

The scalp becomes impermeable under this kind of stress