doi: 10.3389/fneur.2017.00333 Received 26 April 2017 Accepted 26 June 2017 Published 20 July 2017 Volume 8 - 2017 Edited by Vittorio Maglione, IRCCS Neuromed, Italy Reviewed by Jenny Sassone, Vita-Salute San Raffaele University, Italy
Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P
This suggests that its mechanism of action may be unconventional, possibly involving the modulation of multiple downstream pathways or direct interaction with cellular components like growth factor receptors or cytoskeletal proteins
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Levocarnitine was not bound to plasma protein or albumin when tested at any concentration or with any species including the human.9 METABOLISM AND EXCRETION In a pharmacokinetic study where five normal adult male volunteers received an oral dose of [3H-methyl]-L-carnitine following 15 days of a high carnitine diet and additional carnitine supplement, 58 to 65% of the administered radioactive dose was recovered in the urine and feces in 5 to 11 days