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Unlike earlier compounds that focus on a single receptor, Retatrutide interacts with GLP-1, GIP, and glucagon receptors simultaneously

10.1007/s13346-023-01487-5 98 LiuG.LiuJ.ShaoP.KaiD.YangL.SunP.et al (2025)

Clinical experience and real-world patient data show that semaglutide can be safely used alongside levothyroxine or other thyroid replacements when baseline thyroid levels are controlled

however, it's crucial to acknowledge that a substantial portion of individuals tend to experience weight regain once they cease taking the medication

These medications work by mimicking the effects of the natural hormone GLP-1, enhancing insulin secretion, suppressing appetite, and slowing gastric emptying

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