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ROS enhances inflammation by activating MAPK, which subsequently phosphorylates downstream proteins to upregulate the expression of pro-inflammatory genes such as IL-6, TNF-, and IL-1 [90]

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Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-B signal pathway

doi: 10.3390/nu15245053 8

Specifically, insufficient VEGF signaling may disrupt the intricate balance of vasodilation and vasoconstriction, crucial for maintaining optimal blood flow to the brain regions