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Currently, data from clinical studies on resveratrols effect on the thyroid in humans are absent, and all literature evidence is based on studies performed in cell cultures and animal models

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The tissue and cell disruption during processing (e.g., mixing, cutting, crushing, freezing/thawing, and high pressure treatment) makes native polyglutamyl folates accessible for endogenous conjugases (-glutamyl hydrolases) and results in the hydrolysis to monoglutamyl folates in vegetables (e.g., leeks, cauliflower, broccoli, spinach, soybeans, green beans, cowpea leaves, turnip, and carrot) and fruits (e.g., orange, papaya, sweet cherry, strawberry, and blackberry)

[28] This raises the possibility that this extracellular glutamate plays an "endocrine-like" role as part of a larger homeostatic system