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When multiple CALMs are present, the possibility of a neurocutaneous syndrome, most commonly neurofibromatosis type 1, needs to be considered whereas generalized lentiginosis may point to the diagnosis of Carney complex or Noonan syndrome with multiple lentigines (LEOPARD syndrome)

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It is common knowledge that as we age, our skin starts to show signs of aging, becoming pigmented, wrinkled, and saggy

[PMC free article: PMC6067746] [PubMed: 30063751] 96

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