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In multivariate analyses, factors predicting larger responses with tirzepatide include female sex (2.4 higher odds of achieving a 20% weight reduction), lower baseline hemoglobin A1c (1.62 higher odds), no diagnosed hypertension (1.35 higher odds), and lower ALT (1.17 higher odds) 21

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Ideally, this should be distributed somewhat evenly throughout the day

10.1038/s41598-021-00337-z 66 GoldenbergD

Fat, for example, doesnt absorb or metabolize alcohol as well as muscle does, so alcohol becomes concentrated more quickly in people with lots of body fat

Methods and Findings in Experimental and Clinical Pharmacology