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Three patterns are seen: Pattern 1: Medications stay the same, BP drops into ideal range

Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis as a negative feedback mechanism in normal rats

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In addition, gastric acid and digestive enzymes can destroy glutathione, leading to its premature breakdown during digestion and limiting its bioavailability

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