Nature 481 , 385388 (2012)
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Current management for MASLD primarily relies on lifestyle modifications, with limited pharmacological options
Meanwhile, GLP-1 receptor activation in the hypothalamus, specifically in the arcuate nucleus and paraventricular nucleus, directly suppresses hunger signals by activating satiety-promoting POMC/CART neurons while inhibiting hunger-promoting NPY/AgRP neurons
Once diagnosed, many practitioners may not focus on the autoimmune aspect, believing that there is little that can be done to alter the course of the disease
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