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Superoxide combines with NO to form peroxynitrite that oxidizes BH 4 and destabilizes eNOS to produce more superoxide 22, 24, 25 thus, further enhancing the development of oxidative stress

17 In contrast, unlocked nucleic acid (UNA) is a flexible RNA mimic that lacks chemical bonds between the ribose rings C2 and C3 atoms

Health experts note that "these drugs are meant to be taken long-term, and stopping them may lead to weight regain", so affordability matters for the long haul