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If the medicine label includes ER or XL, stay with the extended-release family unless your clinician changes the plan

Is There a Risk of Yo-Yo Effect

Weight Loss Medications in Addiction Recovery Emerging research suggests that some weight loss medications may benefit individuals with co-occurring substance use disorders (SUDs)

Two emerging pharmacological classes may challenge its risk-reward calculus: Oral GLP-1 agonists (e.g., oral semaglutide, danuglipron): These offer dosing convenience and eliminate injection site reactions, but bioavailability remains problematic (oral semaglutide achieves only 0.41% absorption, requiring daily dosing and strict administration protocols)

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Some studies have incorporated a loading regimen with higher initial doses, followed by lower maintenance doses of 1-2mg per week