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GSL2 is a mitochondrial aminotransferase and a direct transcriptional target of P53, which binds to the corresponding element in the GLS2 gene and induces transcription of GLS2, which inhibits ferroptosis by increasing cellular antioxidant capacity by promoting the production of GSH and NADPH (39, 40), but has no direct effect on GPX4 expression through binding the GPX4 promoter (41)

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doi: 10.1038/s41591-022-02129-y 77 KawadaMAmemiyaMYoshidaJOhishiT