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This results in an increase in the cytoplasmic calcium concentration, which enhances insulin secretion from -cells [24,25,26] (Fig

DPP-IV resistance explained: Dipeptidyl peptidase IV cleaves at position 2 of many peptides

Inspect for clarity

comparing metformin, liraglutide, and combination therapy (metformin 1000 mg BID + liraglutide 1.2 mg/day), the latter, and not liraglutide 1.2 mg/day alone, was superior to metformin alone in reducing glucose levels at 120 min during OGTT [61]

Psychiatry 27 , 803818 (2022)

Generic liraglutide has been available since 2024 ( [68] ), and semaglutides US patent exclusivity is set to expire on March 20, 2026, which could further reshape the competitive landscape