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Although oral administration of NR did not have a direct impact on liver status, as revealed by the circulating levels of liver enzymes [97], levels of relevant NR-derived metabolites, especially NAD + and nicotinic acid adenine dinucleotide (NAAD), were significantly elevated in circulating PBMCs of treated human participants [76, 97]

Synthesis of probes All commercially available reagents and solvents were used without additional purification unless stated otherwise

Xu, Y., Buikema, H., van Gilst, W

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Genes Dev 8:18 Adams V, Nehrhoff B, Spte U, Linke A, Schulze PC, Baur A, Gielen S, Hambrecht R, Schuler G (2002) Induction of iNOS expression in skeletal muscle by IL-1beta and NF-B activation: an in vitro and in vivo study