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At night and during darkness, the activity of post-ganglionic sympathetic fibers increases, which leads to the release of norepinephrine (NA) into the pineal gland, where it binds to pinealocyte -AR receptors increasing intracellular cAMP, which is responsible for the phosphorylation of CREB protein, a transcription factor initiating SNAT genes transcription (23, 24)

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