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It could also be involved in maintaining gut barrier functioning, through the synthesis of microbial anti-inflammatory molecules, which regulate cell permeability, preserving tight junctions proteins, and protecting intestinal cells of the mucous layer [55]

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Either genetic or pharmacologic inhibition of TrxR1 activity induces Nrf2 without inducing oxidative stress, indicating that a part of the stress-sensing regulatory mechanism of Nrf2 is controlled by TrxR1 [49, 173176]

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Verma, M

The question was whether the secretagogue influences bone mineral content