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Also known as histamine H2-receptor antagonists (H2RAs), these are used to treat duodenal ulcers and gastric ulcers and can reduce circulating B12 concentrations with prolonged use

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Research on both mice and humans has highlighted the essential role of IL-33 in stimulating ILC2s and Th2 cells to secrete type 2 cytokines, such as IL-5 and IL-13, which trigger allergic responses driven by the innate immune system [178,179,180]

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