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Int J Nanomedicine (2024) 19:252952

In this experimental platform, the anti-gravity calf-muscle group (gastrocnemius (Gas), plantaris (Pla), and soleus (Sol) muscles) and shank muscles (tibialis anterior (TA) and extensor digitorum longus (EDL)) were collected from four experimental groups of 8-week-old C57BL/6J male mice: i) control (without any treatment), ii) 5-days suspension-disuse, iii) 3-days LASSS pre-administration (about 50 g in drinking water/g body weight/day) followed by 5-days suspension-disuse treatment without LASSS supplementation, and iv) 3-days GSSSG pre-administration followed by suspension-disuse treatment ( n = 3 mice per group)

In general, these things are true but some solutes have interesting behaviors that have to be explained

PMID: 31843173

The team also published several studies

Because healthy proliferating cells do not rely on sustained FOXO4p53 sequestration for survival, they are less affected in experimental models