eli lilly phase 3 trial retatrutide The numbers from Lilly's dropped this week and I haven't been able to stop thinking about them. Not only as a doctor but as a long-term GLP-1 user VisualAbstract: Retatrutide reduces body weight

Many patients begin after a pharmacy rejection, portal message, or notice from their doctor

If someone starts a GLP-1 and: Doesn't strength train Doesn't prioritize protein Doesn't track body composition Doesn't monitor waist circumference Doesn't take progress photos Doesn't review training performance ...then yes, they're more likely to lose muscle than necessary

This approach maximizes accuracy during the critical early weeks when your body is still adapting to the peptide and precise dosing matters most

Starting doses for tirzepatide are typically 2.5 mg per week, administered as a subcutaneous injection

Steering clear of strong smells that may trigger nausea

Retatrutide is a once-weekly injection, meaning 52 injections per year instead of 365