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The kidneys also eliminate excess carnitine through urine to maintain healthful concentrations

Glutamate analogs, such as acivicin and DON, are representative GGT inhibitors but have notable glutaminase off-target and cytotoxic effects related to glutamine metabolism [74,75]

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In experimental models, diabetes reduces NGF expression in target tissues including skin and muscle, impairing retrograde transport to neuronal cell bodies and decreasing neuropeptides such as substance P and calcitonin gene-related peptide [146]