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GLP-1 drugs commonly cause nausea, constipation, or an uncomfortable sense of fullness, especially early on, because they slow digestion

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Structure of PEG Loxenatide Tirzepatide Tirzepatide is a dual GIP/GLP-1 receptor agonist that activates both the GLP-1 and GIP signaling pathways

That is comparable to results achieved by taking the highest dose of Lillys other blockbuster weight loss drug, Zepbound

"The decreases we saw will likely show up in a much broader slice of the population" because of weight-loss pills, said Sylvia Hristakeva, one of the study's co-authors

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