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A bidirectional and self-reinforcing mitochondria-inflammation loop in MDD Beyond acting as an upstream trigger, mitochondrial dysfunction and inflammation form a self-amplifying pathological loop that fuels MDD progression [107]

The elderly, especially those already frail, are more susceptible to muscle loss or dehydration from GI distress

doi:10.1093/bjsopen/zraf089

Practical strategies include ensuring adequate caloric and protein intake, wearing thermal layers with attention to extremities, engaging in regular physical activity to maintain metabolic rate, and maintaining ambient temperatures of at least 18C

Fiber slows digestion while improving intestinal transit, helping get food to where the GLP-1 is being produced