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A wrapped ice pack on the site for 30 to 60 seconds before you inject can help numb the area to reduce discomfort

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Some individuals have genetic variants in the GLP1R gene (such as rs6923761) that affect receptor sensitivity, meaning they experience more pronounced nausea or fullness from sugar, while others have variants in FTO or MC4R genes that influence baseline hunger and satiety set points

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They act on receptors primarily the GHRH receptor or the ghrelin receptor (GHS-R1a) to amplify the pituitary's natural signalling

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