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Previous versions of the pen device do not automatically deliver the dose Daily formulations of GLP-1 RAs, including exenatide BID, liraglutide, and lixisenatide, require dose selection and attachment of a disposable needle each time the injection device is to be used

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2 Materials and methods 2.1 Drugs and chemicals To carry out this study, the drugs purchased and used were glycitin and PTZ (Sigma company, United States), phenobarbital ((PB) manufactured by Chemidarou Pharmaceutical company, Iran), ketamine and xylazine (Alfasan Company, Netherlands)

24 , 140.e1140.e5 (2020)

Ann Rev Cell Dev Biol