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BPC-157 operates locally as an **ultra-stable cytoprotectant**: it survives gastric milieu, reactivates the VEGF-receptor-2 pathway at the lesion site, modulates the nitric oxide system (NO / eNOS), upregulates growth hormone receptors on tendon fibroblasts (Chang et al
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Furthermore, our recent work indicates that the viral overexpression of NRF2 in the rodent SVZ can mitigate the decline in NSC function across the critical middle-age period ( Nrf2 / mice have decreased clonogenic and neurogenic potential, as well as an impaired capacity for long-term progression from birth to adulthood in Nrf2 / mice compared to wild-type controls (Robledinos-Antn et al., 2017)
