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doi: 10.3389/fcell.2025.1598924 Received 24 March 2025 Accepted 07 July 2025 Published 18 July 2025 Volume 13 - 2025 Edited by Junqi Huang, Jinan University, China Reviewed by Anna Martina Battaglia, Magna Grcia University of Catanzaro, Italy Cadiele Oliana Reichert, University of So Paulo, Brazil Updates Copyright 2025 Fan, Xu, Gao, Zhang, Wang, Shan, Luo, Fei and Cai

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We previously demonstrated that specific Trkb deletion in iSPNs resulted in age-dependent hyperlocomotor dysfunction, consistent with early hyperkinetic symptoms in HD

They work through different but complementary mechanisms that help maintain healthy cell function