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Indeed, the resultant Ca 2+ influx seems to be necessary for the fusion of insulin granules with the plasma membrane, ending up in its secretion (Hou et al., 2009)

doi:10.1155/2015/818570 [PubMed]\ 103

50 If a patient becomes obtunded and comatose as a result of the APAP overdose, intubation with mechanical ventilation becomes necessary

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