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Although acknowledged in the guidelines of the American Thoracic Society and the European Respiratory Society, more robust studies need to be conducted to further elucidate its applicability [58]

The objective of this review is to provide a comprehensive and structured synthesis of the immunopathogenesis of HT, integrating established knowledge with emerging research areas including oxidative stress, gut microbiota, and epigenetic modifications, while also summarizing current clinical, diagnostic, and therapeutic perspectives (Fig

PCR primers were purchased from Metabion

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