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Probably, the peptides can exhibit different specificities against microorganisms, as observed in mice [151], or the expression level of the -defensin genes along the intestinal tract shows large variations to optimize the local regulation of bacterial colonization [153]

Therapeutic potential of fisetin in hepatic steatosis: insights into autophagy pathway regulation and endoplasmic reticulum stress alleviation in high-fat diet-fed mice

Wegrowski, Y., Maquart, F

These peptides were, Not FDA-approved, but also not explicitly prohibited

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Cell-mediated immunity plays a central role, with nave CD4 + T cells differentiating into effector subsets upon antigen recognition: Th1 cells secrete IFN-, IL-2, and TNF-, inducing MHC class II expression and promoting Fas-mediated apoptosis of thyrocytes