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The effect of semaglutide compared to placebo on estimated GFR was calculated using a MMRM model with two-sided P-values and with fixed effects for treatment, visit, baseline log-transformed UACR, the interaction between treatment and visit, and the interaction between baseline and estimated GFR

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Semaglutide is FDA-approved and has been widely available for both weight loss and diabetes management for a long time

J Am Geriatr Soc 37:843847