Its no wonder, then, that when talking about weight loss today, discussion is dominated by the new GLP-1 (glucagon-like peptide-1) drugs
Weight loss also occurs at lower doses if higher doses are not tolerated due to side effects
Some of these drugs are now also approved to reduce the risk of heart attacks , strokes, and heart-related deaths in certain populations
Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
While these effects can be uncomfortable, most are manageable with small lifestyle changes, hydration, and communication with your healthcare provider
5 Lower doses: Eight in ten real-world patients were on maintenance doses below 1.7 mg of semaglutide or 10 mg of tirzepatide