We know that GLP-1s work across the body and the brain to result in weight loss and that they tamper spikes of feel-good chemicals like dopamine, she says
Liu W, Luo X, Tang J, Mo Q, Zhong H, Zhang H, et al
There is, however, a limit
Interestingly, in type 2 diabetes the insulinotropic action of GIP is markedly blunted, so the role of this component remains a subject of active scientific debate, in preclinical models both agonism and antagonism of GIPR, when combined with GLP-1, reduce body weight
Both medications have the potential to cause gastrointestinal side effects like diarrhea, so the risk may be slightly higher when taking them at the same time
Chronic illness as well as long term toxic exposure can not only deplete stores of glutathione but also inhibit its production