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A recent study 40 showed UA to regulate the transmission of alpha-synuclein in both animal and cellular Parkinsonian models, with a reduction in dopaminergic cell damage

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Kotake, Mie, Koichi Sato, Chihiro Mogi, Masayuki Tobo, Haruka Aoki, Tamotsu Ishizuka, and Noriaki Sunaga et al

The transcription factor ATF4 in turn activates stress-responsive genes such as Tribbles homolog 3 (Trib3) and solute carrier family 7 member 11 (Slc7A11) to mediate protective effects of the integrative stress response 16

Kaymaz B, Glge UH, Ozyalvacl G, Kmrc E, Goksel F, Mermerkaya MU, et al