Seymour, J
These results collectively confirmed that enhanced expression of GSH metabolism and antioxidant enzymes contributes to chemotherapy resistance in breast cancer patients (Fig
10.1038/sj.onc.1209406 Oncogene 100 OhnoS.TakanashiM.SudoK.UedaS.IshikawaA.MatsuyamaN.et al (2013)
This suggests that the conversion of NAC to glutathione supports the functioning of the dopamine system in Parkinsons disease patients, which has been associated with both the physical and the motor effects of the condition
The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)
Lifehacks: If you think you may need to boost your glutathione levels due to oxidative stress and genetic polymorphisms, there are multiple way you could approach this: Reduce the need for glutathione (reduce toxins) Add more cysteine-rich foods its the limiting factor for glutathione synthesis Also, add glycine if it is limited in your diet Directly supplement with liposomal or IV glutathione Indirectly supplement with cofactors, amino acids (caution here) Avoiding toxicants: Avoiding exposure to the toxicants that deplete glutathione will increase your overall glutathione levels and give you more resistance to oxidative stress
