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2B) and low-PD-L1 (Fig

Bagherani N, Yaghoobi R, Omidian M

Toxicities associated with this treatment included mucocutaneous symptoms, abnormalities in liver function tests and triglyceride levels, and musculoskeletal symptoms such as arthralgias, calcifications of tendons and ligaments, and osteoporosis.[256,257] Dose reduction to 0.5 mg/kg/day reduced toxicity and decreased skin cancer frequency in three of seven subjects (43%)

It usually mimics heart failure symptoms and can also present with arrhythmias and conduction abnormalities

The authors determined serum levels of urotensin receptor (UTS2R), a peptide present in the heart and blood vessels

10.1016/S0952-7915(01)00303-X