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They contain food-grade silica (silicon dioxide) and protect the product by absorbing moisture that enters the can each time it is opened

Progesterone generates a metabolite known as allopregnanolone, which impacts the GABA receptors

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doi:10.1007/s10558-010-9092-1

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For women with robust glutathione levels and healthy detoxification pathways, occasional use at recommended doses appears to pose minimal risk