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The study compares tirzepatide with the long-acting GLP-1 RA, dulaglutide for non-inferiority and superiority, and is currently in progress [61]

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More research will help define long-term safety and how dosing should be managed over time

We could expect from early treatment with oral semaglutide and other GLP-1 analogues a better control of cardiovascular risks as a result of its actions exerted before atherosclerosis develops, in addition to the benefits of superior glucose control and weight loss

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Higher efficacy Aside from pricing competition and label expansion, greater efficacy in HbA1c reduction and/or weight loss, reduced side-effects and increased patient convenience (eg an oral tablet rather than a subcutaneous injection) will also contribute to the success of new GLP-1s and associated weight loss medication