doi: 10.1002/dta.1941
Although these mechanisms were initially elucidated in patients with T2D, the distinct yet complementary actions of these two drug classes suggest that their combination could provide more comprehensive therapeutic benefits than either agent alone, potentially offering a more effective approach to managing the complex pathophysiology of MASLD and its associated metabolic complications
PMID: 16928994 Loeys BL, Chen J, Neptune ER, Judge DP, Podowski M, Holm T, Meyers J, Leitch CC, Katsanis N, Sharifi N, Xu FL, Myers LA, Spevak PJ, Cameron DE, De Backer J, Hellemans J, Chen Y, Davis EC, Webb CL, Kress W, Coucke P, Rifkin DB, De Paepe AM, Dietz HC
However, participants given apitegromab alongside tirzepatide lost on average 1.6kg (3.5lb) of lean mass (corresponding to 14.6% of total weight loss) while those given tirzepatide alongside a placebo lost on average 3.5kg of lean mass
Cani PD, Lecourt E, Dewulf EM, et al
Understanding what each agent is and what it is not is essential before drawing any meaningful comparison