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Despite great advances in the mechanistic understanding of inherited channelopathies, translation of mechanism-based novel therapies into clinical use remains challenging due to problems in designing and funding clinical studies with sufficient power in these rare diseases, particularly for second use applications of already approved drugs

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Pyrroloquinoline quinone attenuates isoproterenol hydrochloride-induced cardiac hypertrophy in AC16 cells by inhibiting the NF-B signaling pathway

As pH gradually increases, the primary dissociation of phosphate groups occurs first (dissociation curve I), followed by the secondary dissociation of phosphate groups (III)

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