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Regular IGF-1 (also called IGF-1 DES) has a half-life of only 20-30 minutes because IGF-binding proteins (IGFBPs) rapidly deactivate it

This Review focuses on the contributions of the following factors: age-related inflammation (also referred to as 'inflammaging')

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They match the kind of effect a clinician can see: faster return of function, quicker reduction in pain, earlier tolerance of loading, a shorter gap between injury and I feel normal again. But this is where we have to be clinically honest